Organooxygen compounds
Medchemexpress LLC Simufilam hydrochloride (PTI-125 hydrochloride) | 2480226-07-9 | 99.9% | 295.81 | 25 MG
Simufilam hydrochloride (PTI-125 hydrochloride) is an orally active FLNA modulator. It restores NMDAR signaling and Arc expression. It inhibits overactive mTOR signaling by restoring the normal conformation of FLNA, improves insulin sensitivity, reduces Aβ42-induced neuroinflammation, and tau protein hyperphosphorylation. This product can be used for research related to Alzheimer's disease.
- Reduces FLNA-α7nAChR/TLR4 associations and dissociates Aβ42-α7nAChR complexes.
- Restores α7nAChR/NMDAR/IR function and NMDAR signaling and arc expression in human AD brain slices.
- Decreases tau phosphorylation, Aβ42 aggregates, and inflammatory cytokines in mouse models.
- Improves NMDAR/IR function, synaptic plasticity, spatial/working memory, and nesting behavior in 3xTg AD mice.
Medchemexpress LLC 1-Undecanol | 112-42-5 | 172.31 | 10 MM * 1 ML
1-Undecanol is primarily produced from the degradation of 2-tridecanone by Pseudomonas bacteria isolated from soil. It has been shown to enhance the attraction of Grapholita molesta to sex pheromone traps.
- Primarily produced from the degradation of 2-tridecanone by Pseudomonas bacteria isolated from soil.
- Enhances the attraction of Grapholita molesta to sex pheromone traps.
- Acts as a synergist for the sex pheromone of Grapholita molesta.
![Medchemexpress LLC Benzoic acid, 4-[4-[[(3R)-1-butyl-3-[(R)-cyclohexylhydroxymethyl]-2,5-dioxo-1,4,9-triazaspiro [5.5]undec-9-yl]methyl]phenoxy]-, hydrochloride (1:1) | 461023-63-2 | 99.9% | 614.17 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000386677-logo.png-250.jpg){kind=logo}
Medchemexpress LLC Benzoic acid, 4-[4-[[(3R)-1-butyl-3-[(R)-cyclohexylhydroxymethyl]-2,5-dioxo-1,4,9-triazaspiro [5.5]undec-9-yl]methyl]phenoxy]-, hydrochloride (1:1) | 461023-63-2 | 99.9% | 614.17 | 1 ML
Aplaviroc hydrochloride, an SDP derivative, is a potent CCR5 antagonist. It exhibits strong activity against various HIV-1 strains, including wild-type and multidrug-resistant variants, by binding to CCR5 with high affinity and inhibiting gp120/CD4 binding. This compound has been shown to suppress R5 HIV-1 viremia in in vivo models.
- Potent activity against three wild-type R5 HIV-1 strains (HIV-1Ba-L, HIV-1JRFL, and HIV-1MOKW).
- Substantially more potent than previously published CCR5 inhibitors.
- Suppresses infectivity and replication of two HIV-1MDR variants.
- Binds to CCR5 with high affinity.
- Potently blocks rgp120/sCD4 binding to CCR5.
- Exerts potent anti-R5 human immunodeficiency virus type 1 effects in a novel AIDS mouse model.
- Suppresses R5 HIV-1 viremia in hu-PBMC-NOG mice.
Medchemexpress LLC SRI-37330 hydrochloride | 2322245-49-6 | 99.7% | C16H20ClF3N4O2S | 25 MG
SRI-37330 hydrochloride is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. It inhibits glucagon secretion and function, reduces hepatic glucose production, and reverses hepatic steatosis. This compound can be used for type 2 diabetes research.
- Inhibits activity of human TXNIP promoter in INS-1 cells.
- Decreases mRNA and protein levels of TXNIP in INS-1 cells.
- Inhibits polymerase II (Pol II) binding to the E-box motif region of the TXNIP promoter.
- Lowers glucagon secretion in TC1-6 cells.
- Inhibits glucagon-induced glucose output from primary hepatocytes.
- Decreases glucagon secretion and action in mice.
- Blocks hepatic glucose output in mice.
- Reverses obesity- and streptozotocin-induced diabetes and hepatic steatosis in mice.
- Well tolerated in male C57BL/6J mice.
Medchemexpress LLC 3,6,9,12,15,18,21-Heptaoxatricosan-1-ol, 23-azido- | 352439-36-2 | 97.0% | C16H33N3O8 | 250 MG
Azide-PEG8-alcohol is a PEG-based PROTAC linker that functions as a click chemistry reagent with an Azide group. It participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne groups, and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. This molecule is used in the synthesis of PROTACs, which harness the ubiquitin-proteasome system for selective protein degradation.
- Peg-based PROTAC linker
- Utilized in PROTAC synthesis
- Click chemistry reagent
- Features an Azide group
- Enables CuAAc reactions with alkyne groups
- Enables SPAAC reactions with DBCO or BCN groups
Medchemexpress LLC Flavoxate (hydrochloride) | 3717-88-2 | 99.7% | 25 MG
Flavoxate hydrochloride (Standard) is an analytical reference standard used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS. It is an orally active L-type Ca2+ channel inhibitor and antispasmodic agent. It functions as a potent and competitive phosphodiesterase inhibitor and a muscarinic mAChR antagonist, demonstrating moderate calcium antagonistic activity and local anesthetic effect.
- Inhibits cyclic adenosine monophosphate production
- Regulates the brainstem micturition center
- Stimulates G protein-coupled receptors
- Relaxes bladder smooth muscle
- Inhibits isovolumetric rhythmic contractions
- Increases bladder capacity
- Reduces urgent urination frequency and pollakiuria symptoms
- Suitable for overactive bladder and lower urinary tract infection research
Medchemexpress LLC Lidocaine hydrochloride hydrate | 6108-05-0 | 99.8% | 50 MG
Lidocaine hydrochloride hydrate is a sodium channel blocker that inhibits sodium channels with complex voltage and use dependence. It decreases the growth, migration, and invasion of gastric carcinoma cells by up-regulating miR-145 expression and inactivating the MEK/ERK and NF-κB signaling pathways. This amide derivative shows potential for research into ventricular arrhythmia.
- Inhibits sodium channels
- Decreases growth, migration, and invasion of gastric carcinoma cells
- Upregulates miR-145 expression
- Inactivates MEK/ERK and NF-κB signaling pathways
- Decreases cell proliferation and viability in MKN45 cells
- Increases apoptotic cell rate in MKN45 cells
- Down-regulates Cyclin D1 and up-regulates p21 expression in MKN45 cells
Medchemexpress LLC Pirlimycin hydrochloride | 78822-40-9 | MFCD27952783 | 99.1% | 447.42 g·mol⁻¹ | C17H32Cl2N2O5S | 1 MG
Pirlimycin hydrochloride is a lincosamide-class antibiotic supplied as the hydrochloride salt for research use. It inhibits bacterial protein synthesis by binding the 50S ribosomal subunit and is primarily active against Gram-positive organisms. The material is provided as a solid at high purity for analytical and laboratory applications.
- Lincosamide antibiotic.
- Inhibits bacterial protein synthesis via 50S ribosomal binding.
- Primarily active against Gram-positive bacteria.
- High purity (99.1%).
- Supplied as a solid suitable for analytical use.
- Available in small-scale quantities for research.
eMolecules 108-93-0 | Cyclohexanol | Combi-Blocks | MFCD00003855 | 100.161 | C6H12O | 98.000 | OC1CCCCC1 | 500g | 439369297
Cyclohexanol | Combi-Blocks | 108-93-0 | MFCD00003855 | 100.161 | C6H12O | 98.000 | OC1CCCCC1 | 500g | 439369297
Medchemexpress LLC Flavoxate hydrochloride | 3717-88-2 | 99.7% | 250 MG
Flavoxate hydrochloride is the analytical standard of Flavoxate (hydrochloride), intended for research and analytical applications. It is a potent and competitive phosphodiesterase (PDE) inhibitor, an antispasmodic agent, and a muscarinic mAChR antagonist. It exhibits moderate calcium antagonistic activity and a local anesthetic effect. This product can be used for the research of overactive bladder (OAB) and lower urinary tract infections.
- Analytical standard for research and analytical applications.
- Potent and competitive phosphodiesterase (PDE) inhibitor.
- Antispasmodic agent.
- Muscarinic mAChR antagonist.
- Shows moderate calcium antagonistic activity.
- Possesses local anesthetic effect.
- Applicable for research on overactive bladder (OAB) and lower urinary tract infections.
- Used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
Medchemexpress LLC Ravidasvir hydrochloride | 1303533-81-4 | MFCD32705191 | 99.9% | 835.82 | C42H52Cl2N8O6 | 50MG
Ravidasvir hydrochloride is the hydrochloride salt of ravidasvir, a pan-genotypic hepatitis C virus (HCV) NS5A inhibitor supplied as a high-purity research compound in solid form. It inhibits HCV replication at low nanomolar concentrations and is provided for laboratory research applications.
- High purity (99.9%).
- White to off-white solid physical form.
- Molecular weight 835.82 g/mol.
- Packaged as 50 MG for research use.
- Storage: sealed at 4°C; in solvent: -80°C (up to 6 months) or -20°C (up to 1 month).
- Provides potent pan-genotypic NS5A inhibition with low nanomolar activity.
eMolecules 849928-26-3 | TERT-BUTYL 3-BROMOPIPERIDINE-1-CARBOXYLATE | AstaTech | MFCD07779077 | 264.163 | C10H18BrNO2 | 95.000 | CC(C)(C)OC(=O)N1CCCC(Br)C1 | 5g | 335875729
TERT-BUTYL 3-BROMOPIPERIDINE-1-CARBOXYLATE | AstaTech | 849928-26-3 | MFCD07779077 | 264.163 | C10H18BrNO2 | 95.000 | CC(C)(C)OC(=O)N1CCCC(Br)C1 | 5g | 335875729
Medchemexpress LLC 1-naphthyl 3,5-dinitrobenzoate | 93261-39-3 | MFCD00376091 | >=98.0% | 338.27 g/mol | C17H10N2O6 | 1MG
1-Naphthyl 3,5-dinitrobenzoate is a small-molecule biochemical reagent used as a dual inhibitor of 5-lipoxygenase (5-LOX) and microsomal prostaglandin E synthase-1 (mPGES-1). Supplied as a crystalline solid, it is used in inflammation and lipid mediator research to probe enzyme activity and signaling pathways. Molecular formula C17H10N2O6; molecular weight 338.27 g/mol; reported IC50 values ≈1 μM (5-LOX) and ≈3.6 μM (mPGES-1).
- Potent dual inhibitor for use in target validation and pathway studies.
- High-purity crystalline solid suitable for biochemical assays.
- Well characterized molecular formula and molecular weight for analytical work.
- Stable when stored at low temperature for extended shelf life.
- Available in small research quantities for lab-scale experiments.
Medchemexpress LLC 3-Methyl-2-buten-1-ol | 556-82-1 | 99.8% | 86.13 | 1 ML
3-Methyl-2-buten-1-ol (MBO321) is an orally active endogenous metabolite found in pine trees and is used as a fragrance ingredient in cosmetics and detergents. It passes the cell barrier and has been shown to reduce body weight in rats.
- Endogenous metabolite
- Orally active
- Found in pine trees
- Used as a fragrance ingredient in cosmetics and detergents
- Passes cell barrier
- Reduces body weight in rats
eMolecules 59247-47-1 | tert-Butyl 4-bromobenzoate | Ambeed | MFCD00093266 | 257.127 | C11H13BrO2 | 97.000 | CC(C)(C)OC(=O)c1ccc(Br)cc1 | 5g | 490497488
tert-Butyl 4-bromobenzoate | Ambeed | 59247-47-1 | MFCD00093266 | 257.127 | C11H13BrO2 | 97.000 | CC(C)(C)OC(=O)c1ccc(Br)cc1 | 5g | 490497488